CareLit Fachartikel
A molecular signature for identification of platinum resistant ovarian cancer
T Fehm, M Bonin, J Hoffmann, K Sotlar, E Solomayer, H Neubauer · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09
Dokument
1103833
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
Nearly all patients with ovarian cancer are treated with platinum-based chemotherapy postoperatively. Since so far molecular profiling of platinum resistant ovarian tumors does not play a role in the selection of adjuvant therapy the goal of this study was to identify a set of genes, which can predict resistance to platinum-based chemotherapy. Twelve platinum resistant and 12 platinum sensitive ovarian carcinomas were selected by a pathologist who defined the subtype and the proportion of carcinoma. Only samples containing at least 50% malignant tissue were used to isolate RNA from frozen tissue sections and wer…
Schlagworte
molecular signature
ovarian cancer
platinum resistance
Data Analysis
Apoptosis
Geburtshilfe und Frauenheilkunde
