CareLit Fachartikel

Intrauterine use of hyerconcentrated platelet concentrates collected with Trima Accel(TM) in neonatale alloimmune thrombocytopenia

JWM Engel, TW Goecke, M Schroth, F Faschingbauer, J Ringwald, RL Schild · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09

Dokument
1103840
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
JWM Engel, TW Goecke, M Schroth, F Faschingbauer, J Ringwald, RL Schild
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-12 00:00:00
ISSN
0016-5751
DOI
10.1055/s-0028-1088927

Zusammenfassung

Neonatal alloimmune thrombocytopenia (NAIT) is a clinical syndrome that is characterized by marked thrombocytopenia and antenatal intracranial hemorrhage in the fetus or neonate occurring before or shortly after birth. NAIT is caused by the diaplacental transfer of maternal antibodies against human PLT antigens (HPA) carried by the PLTs of the fetus. Among Caucasian population, the most common antibodies are directed against HPA–1a and HPA–5b. Such maternal antibodies are detectable in approximately 1 in 350 pregnancies. Up to 25% of the cases, however, remain clinically silent. So the birth of a first affected…

Schlagworte

NAIT Trima Accel(TM) intrauterine use of platelet concentrate neonatale alloimmune thrombocytopenia Antibodies Population Antigens Apheresis After Geburtshilfe und Frauenheilkunde