Functional Toll-like receptor 5 gene variants are not associated with susceptibility to inflammatory bowel disease in the German population
J Glas, J Seiderer, B Sandner, E Paschos, C Tillack, J Diegelmann, S Pfennig, HP Török, B Göke, T Ochsenkühn, M Folwaczny, B Müller-Myhsok, S Brand · Zeitschrift für Gastroenterologie · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background and Aims: Toll-like receptor 5 (TLR5), the pattern recognition receptor for bacterial flagellin, plays an important role in innate immunity. We recently identified TLR4, the receptor for lipopolysaccharide, as a susceptibility gene for Crohn's disease (CD) (Inflamm Bowel Dis 2005;11:645–52). We therefore investigated the role of TLR5 variants on susceptibility and phenotype of inflammatory bowel disease (IBD). Methods: Genomic DNA from 594 Caucasian individuals including 190 patients with CD, 139 patients with ulcerative colitis (UC), and 265 healthy unrelated controls was genotyped for the SNPs rs574…
