Combination therapy with Adefovir and Entecavir is well tolerated and effective in Lamivudine-resistant chronic Hepatitis B

Methods: 26 patients (pts) (23 male/3 female, age 49.3 (27.7–72.2yrs) with chronic hepatitis B (13 pts HBeAg pos) who were pretreated with and resistant to lamivudine received combination therapy with entecavir 1mg and adefovir 10mg daily. 9 pts (33%) had cirrhosis, none of them decompensated (MELD score 9, (6–13)); The mean duration of lamivudine pretreatment was 23 months (2–122 mo). In 10 pts lamivudine had been stopped or changed to another treatment more than 24 wks before the start of this study. 8 (30%) were switched directly from lamivudine monotherapy (5 pts) or combination therapy with lamivudine and a…