CareLit Fachartikel
„Gene therapy“: from bench to bedside?
B Spänkuch · Geburtshilfe und Frauenheilkunde · 2009 · Heft 02
Dokument
1104206
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Polo-like kinase 1 (Plk1) constitutes a potential drug target which attracts increasing attention in the field of cancer therapy, because this serine/threonine kinase is a key regulator for the mitotic progression of mammalian cells and a spindle checkpoint modulator (1). Plk1 shows elevated activity in all cancer cells analyzed to date (2, 3) and it has prognostic value for predicting outcomes in patients with several cancers (4). The importance of Plk1 as a measure for the aggressiveness of a tumor results from its important role for the mitotic checkpoints of cancer cells (5–8). Deletion or mutations in Plk-c…
Schlagworte
Breast
Apoptosis
Tumor
After
Carboplatin
Albumin-Bound Paclitaxel
Cyclin B1
ABI 007
ABI-007
Attention
Caspase 3
Abraxane
Actin
Geburtshilfe und Frauenheilkunde
