CareLit Fachartikel
Profibrotic impact of TGF-β1 on gene expression in primary mouse hepatocytes
I Ilkavets, P Godoy, A Bachmann, S Dooley · Zeitschrift für Gastroenterologie · 2009 · Heft 01
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1104275
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Jahr
2009
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Zusammenfassung
Transforming growth factor beta 1 (TGF-β1) is a key effector cytokine in liver fibrosis. Although the intense investigations, the mechanisms of liver fibrosis remain elusive. In this study, we aimed to identify signaling pathways that are differentially regulated upon TGF-β1 stimulation and might serve as markers for enhanced pathophysiological level of TGF-β1 in liver. By a genome-wide gene expression profiling, we identified 2,196 differentially regulated genes. Using KEGG and David tools, the TGF-β1 gene targets were mapped into annotated pathways, revealing relationships broadly altered in primary mouse hepa…
Schlagworte
TGF-β1
fibrosis
hepatocyte
liver
microarray
signaling
Cytokine
Zeitschrift für Gastroenterologie
