CareLit Fachartikel
TGF-β1 mediated Smad1/Smad5 signalling modulates transdifferentiation of hepatic stellate cells
SK Meurer, L Tihaa, R Weiskirchen · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Dokument
1104276
CareLit-ID
Jahr
2009
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Aims: The main cellular source of extracellular matrix (ECM) in the fibrotic liver are myofibroblast like cells (MFB). MFB originate from activated hepatic stellate cells (HSC) through a process called „transdifferentiation“. Both transdifferentiation and the fibrotic response of activated HSC are regulated by TGF-β1/ALK5/Smad3 signalling. In addition an involvement of TGF-β1/ALK1/Smad1 in these processes has been postulated [1]. Methods and Results: During transdifferentiation of primary HSC into MFB, Smad1/Smad5 proteins are highly phosphorylated at their C-termini. Inhibition of Smad1/Smad5-signalling using a…
Schlagworte
ALK1
Fibrosis
Smad1
TGF-beta1
Tgf-Β1
Transdifferentiation
Activated
Smad5
Activation
Runx2
Signalling
Cells
Fibrotic
Through
Smad3
Zeitschrift für Gastroenterologie
