Chronic Alcohol Feeding Stimulates the Formation of Mutagenic Etheno-Adducts in a Rodent model of NASH Via Induction of Cytochrome P450 2E1
F Stickel, E Patsenker, Y Wang, V Schneider, M Ledermann, H Saegesser, S Mueller, HK Seitz · Zeitschrift für Gastroenterologie · 2009 · Heft 01
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Zusammenfassung
Background and Aims: Chronic alcohol consumption may cause liver fibrosis and hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD). Synergistic effects of insulin resistance and alcohol triggering fibrogenesis and HCC are implicated. Formation of mutagenic etheno adducts binding to adenosin (EdA) generated via induced CYP2E1 has been suggested as a key mechanisms of hepatocarcinogenesis. Methods: Obese Zucker rats and lean littermates (4 groups) received Lieber-De Carli liquid diets containing either ethanol or carbohydrates for 3 months. Fibrosis and steatosis were quantified by Sirius Re…
