CareLit Fachartikel
Augmenter of Liver Regeneration inhibits angiogenesis and invasiveness in hepatocellular carcinoma
R Dayoub, H Wagner, C Hackl, O Stöltzing, HJ Schlitt, TS Weiss · Zeitschrift für Gastroenterologie · 2009 · Heft 01
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1104283
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Jahr
2009
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Zusammenfassung
Hepatocellular carcinoma (HCC) is one of the most common malignant disorders, and in some parts of the world represents the most important neoplastic cause of death. In general, HCC represents a hypervascularized cancer and its progression depends on different factors like angiogenesis and invasiveness. Several studies showed that the transcription factor Hypoxia-Inducible Factor 1-alpha plays a central role in HCC progression, angiogenesis and neovascularization. Hif-1 alpha can directly activate the expression of different pro-angiogenic factors like VEGF, VEGFR and angiopoietins. Furthermore, we have shown th…
Schlagworte
Augmenter of Liver Regeneration
HCC
Hif-1alpha
angiogenesis
hypoxia-inducible factor
invasiveness
metastasis
Angiopoietins
Tumor
Zeitschrift für Gastroenterologie
