CareLit Fachartikel
CD8 T cell mediated immune response against cross-presenting liver sinusoidal endothelial cells leads to hepatitis
D Stabenow, K Gärtner, HP Dienes, M Odenthal, U Protzer, PA Knolle · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Dokument
1104288
CareLit-ID
Jahr
2009
Publikation
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
HBV-specific CD8 T cells responses are considered to be targeted directly against HBV-infected hepatocytes leading to development of hepatitis. However, previous work by Schirmbeck et al revealed that CD8 T cells recognizing a peptide in the context of H2Kb, which is exclusively presented by cross-presenting cells, leads to elevated ALT levels. This supported the hypothessis that recognition of antigen on non-hepatocytes leads to CTL-mediated liver disease. To directly investigate the role of non-parenchymal liver cells in initiating of hepatitis, we employed transgenic mouse lines with cell-type specific expres…
Schlagworte
hepatitis
Adoptive Transfer
After
Antigen Presentation
Cytokines
Lead
Work
Zeitschrift für Gastroenterologie
