Favorable Clinical Outcome in Cholangiocellular Carcinoma is Associated with the CC Genotype in the GNB3 825 C>T SNP – a Putative Novel Independent Prognostic Marker

Background/Aims: Cholangiocellular carcinoma (CCA) has a devastating prognosis. While markers enabling a precise prediction of the clinical outcome have long remained scarce, certain single-nucleotide polymorphisms (SNPs) in genes that modulate G protein-signal transduction and apoptosis were recently identified as potential predictive parameters. We here aimed at extending the panel of SNPs suitable for predicting the outcome of CCA. Methodology: Forty Caucasian patients with CCA (and a control collective of 40 age- and sex-matched healthy white Caucasians) were genotyped to simultaneously elucidate putative as…