Diagnosis of latent tuberculosis infection in HIV-seropositive individuals by interferon-gamma release assays

Background: We ascertained the performance of T-cell interferon-gamma release assays (IGRA) for the diagnosis of latent tuberculosis infection (LTBI) in patients with HIV-infection in an area of TB endemicity. Methods: Tuberculin skin test, Quantiferon Gold in tube and T-Spot.TB assays were performed on the peripheral blood of newly diagnosed HIV+ individuals without signs and symptoms of active tuberculosis at an outpatient clinic at Makerere University in Kampala, Uganda. Results: At time of analysis, 134 individuals were enrolled. Median number of CD4+ T-cells was 257/microL). For the TST, QTF-GIT, and T-Spot…