Changes in coherence between left and right substantia nigra heralds the occurence of generalized seizures in genetic absence epilepsy rats from Strasbourg

Introduction: The aim of our study was to investigate the preictal period in the basal ganglia of Genetic Absence Epilepsy Rats from Strasbourg (GAERS). Particularly, we were interested in synchronization before epileptic discharges occur. Methods: We investigated changes between bipolar electrodes within the substantia nigra pars reticulate (SNr) in GAERS before the occurrence of spike and wave discharges (SWD). These episodes were compared with episodes during sleep and wakefulness without SWD. The coherence analysis was performed using two bipolar derivations between both electrodes within left and right SNr.…