CareLit Fachartikel
Physiology of the endothelium: from a molecular point of view
I Fleming · Zeitschrift für Geburtshilfe und Neonatologie · 2009 · Heft 03
Dokument
1104508
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
The endothelium plays a crucial role in the prevention of vascular inflammation and the events leading to atherosclerosis mainly by the generation of anti-inflammatory autacoids. The most important endothelium-derived autacoid is the vasodilator nitric oxide (NO) which influences the expression of several vascular genes in addition to its acute effects on vessel tone. One particularly interesting example of the effect of NO on signalling is its role in the shear stress-induced activation of the AMP-activated protein kinase (AMPK). This NO-activated kinase phosphorylates and inactivates the HMG CoA reductase in e…
Schlagworte
Carotid Arteries
Arteries
Atherosclerosis
Calmodulin
Cytochrome
Autacoids
Zeitschrift für Geburtshilfe und Neonatologie
