Hops contribute to the clinical efficacy of a fixed valerian hops extract combination in patients with primary insomnia. A placebo controlled, double-blind, randomized and prospec…

Valerian and hops are traditionally used as sleep aids. Valerian extract acts like adenosine which is a sleep promoting endogenous transmitter. Hops, on the other hand, influence the circadian entrainment like melatonin. Therefore the combination of both of the extracts seems meaningful. However, as the fixed valerian and hops extract combination Ze 91019 has to be seen as the pharmacological active principle, the clinical efficacy must be demonstrated for this combination. Pharmacodynamic actions [1] as well as efficacy in an uncontrolled study in patients suffering from non-organic sleep disorders [2] have alr…