CareLit Fachartikel
Inhibition of TCF-signalling by triterpenoids from Boswellia carterii induces G0/G1 checkpoint arrest and apoptosis in human prostate cancer cells
T Syrovets, AC Estrada, B Büchele, T Simmet · Zeitschrift für Phytotherapie · 2006 · Heft 11
Dokument
1104572
CareLit-ID
Jahr
2006
Publikation
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Zusammenfassung
Prostate cancer (PC) is one of the most common and deadly cancer types in men. Triterpenoids such as acetyl-11-keto-β-boswellic acid (AKβBA) and 3-keto-tirucallic acid (KTA) induce accumulation of PC cells in the G0/G1 phase followed by induction of apoptosis. Here, we further analyzed the molecular mechanisms involved in the PC cell death induced by AKβBA and KTA. The retinoblastoma protein (RB), a tumor suppressor controlling G1 to S-phase transition, is activated by phosphorylation. Treatment of PC cells with AKβBA and KTA led to RB dephosphorylation. The phosphorylation of RB is controlled by cyclin/cdk comp…
Schlagworte
Cyclin D1
Apoptosis
Boswellia
Cyclin E
Tumor
Zeitschrift für Phytotherapie
