Quantitative assessment of haemosiderosis of liver and spleen by MRT in children with neuroblastoma in contrast to other malignant solid tumors

Objective: Different from other paediatric solid tumours (ST) neuroblastoma contains, synthetizes and actively secretes ferritine depending on the tumour mass present and the exogenous iron supply. Erythrocyte transfusions (RBC-Tx) are the major iron source becoming mandatory following antineoplastic treatment. In comparison to children with other ST and non-malignant controls we assessed subjectively and quantitatively by MRT the hepatospleno-haemosiderosis in neuroblastoma prior, during and after treatment and correlated the data with RBC-Tx. Methods: 132 MRT were performed in 43 children with ST (n=24; neurob…