CareLit Fachartikel
Characterization of HLA-A*0201 restricted cytotoxic CD8+ T cells directed against ewing tumor specific antigens
S Pirson, U Thiel, H Bernhard, GHS Richter, S Burdach · Klinische Pädiatrie · 2009 · Heft 05
Dokument
1104914
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
The rationale of adoptive T cell therapy is based on the attempt to circumvent pre-existing tolerance mechanisms by stimulating potentially tumor-reactive T cells ex vivo. Efforts to eradicate cancer by adoptive T cell transfer have been limited due to the difficulty of isolating tumor-reactive T cells present in low numbers in peripheral blood of tumor patients. Furthermore, the development of an effective immunotherapy in the autologous context is hampered by the deficit of an effective T cell repertoire against tumor antigens. We have optimized the techniques for isolating and expanding antigen-specific allog…
Schlagworte
Tumor
Antigens
Dendritic Cells
Blood
Transplantation
Klinische Pädiatrie
