Inhibition of metastasis by overexpression of caspase-8 in a mouse xenograft model of Ewing Sarcoma

Ewing's Sarcoma (ES) is the second most common bone tumor in childhood and adolescence. Prognosis is particularly poor in patients with metastatic and recurrent disease, with an overall survival of around 20%. Recently, lack of caspase-8 expression has been shown to be linked to the formation of metastasis in neuroblastoma. In previous studies we were able to show that: 1. in a mouse xenograft model of ES development of metastasis is suppressed by application of interferon-γ and 2. interferon-γ promotes the expression of caspase-8 in caspase-8-deficient ES cell lines. In order to study the influence of caspase-8…