Characterization of the t(7;12) chromosomal translocation in infant AMLs: coexpression of T-cell markers, distinct expression of homeobox genes and inhibition of the non-canonical…
S Wildenhain, J Hauer, S Röttgers, H Engelmann, V Binder, R Slany, WD Ludwig, J Harbott, A Borkhardt · Klinische Pädiatrie · 2009 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: The chromosomal translocation t(7;12) was described in MLL negative acute myeloid leukemias of infancy associated with a very poor prognosis. The rearrangement involves the homeobox gene HLXB9 (7q36) and ETV6 (12p13). Methods: Leukemic bone marrow samples of 42 infants, diagnosed in Germany with AML and no 11q23 rearrangement were screened for the fusion transcript HLXB9/ETV6 with RT-PCR. Positive samples were cloned and sequenced. Real-time PCR was performed with specific Taqman primer probe assays (ABI). Results: A fusion transcript was found in approx. ˜18% of MLL-negative infant AMLs. Common fe…
