CareLit Fachartikel
Non-alcoholic steatohepatitis sensitizes to TLR9-induced liver injury
T Csak, A Dolganiuc, B Nath, J Patrasek, K Kodys, G Szabo · Zeitschrift für Gastroenterologie · 2009 · Heft 05
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1104981
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Jahr
2009
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Zusammenfassung
Background/Aims: Inflammatory activation superimposed over non-alcoholic fatty liver disease (NAFLD) results in the clinical syndrome known as non-alcoholic steatohepatitis (NASH). Increased susceptibility of fatty liver to damage induced by ischemia or the TLR4 ligand, lipopolysaccharide, has been previously shown. The effect of other pathogen-derived insults is yet to be delineated. The aim of this study was to evaluate the effect of TLR9 ligand stimulation in a mouse model of NASH. Methods: C57/Bl6 mice were fed methionine-choline deficient (MCD) or supplemented (MCS) diets for 5 weeks and challenged with the…
Schlagworte
Diet
Cytokines
Choline
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After
Zeitschrift für Gastroenterologie
