Investigation of ion transport activities in normal and ulcerative colitis human colonic epithelial cells

Introduction: It has been shown in animal studies that acid/base transporters influence the activities of inflammatory process in inflammatory bowel diseases. There are only scarce available data on the activities of these ion transporters in the normal and inflamed human colon. The aims of our study were to determine the resting intracellular pH (pHi), the activities of Na+/H+ exchangers (NHEs) and the Cl-/HCO3- exchangers (AEs) in colonic crypts isolated from patients with mild or moderate ulcerative colitis [UC] and patients with no colonic disease. Methods: 6 colonic biopsies were obtained from each patient…