Analysis of peroxisome proliferator-activated receptor polymorphisms in inflammatory bowel disease
K Palatka, S Poliska, M Papp, A Penyige, P Lakatos, P Miheller, T Molnár, I Altorjay, L Nagy · Zeitschrift für Gastroenterologie · 2009 · Heft 05
Bibliografische Angaben
Zusammenfassung
Peroxisome proliferator-activated receptor gamma (PPARg), is a ligand-activated transcription factor which regulates gene expression. PPARg is highly expressed in the colon, inhibiting the NF-kB activated pathway, an anti-inflammatory effect of PPARg is observed. 5-aminosalicylic acid (5-ASA) is a PPARg ligand which can induce inflammatory genes repression. Our goal was to characterize some of these SNPs in a cohort of Crohn's disease (CD), ulcerative colitis (UC). A Hungarian Cohort study of 629 CD and 103 UC patients and 491 controls were investigated. We examined two PPARg SNPs: Pro12Ala (exon B) and His447Hi…
