Essential tremor – is there white matter pathology?

Essential tremor is the most frequent movement disorder. Neuropathologic studies of the disease are rare, and there is conflicting evidence for the involvement of white matter structures in the current literature. In this study, we recruited a set of ET patients with a matched control group. We acquired DTI data optimised for high signal-to-noise ratio and low susceptibility artefacts to test whether there is white matter pathology in ET as detectable by non-invasive diffusion MRI. We aim to study 40 subjects in total. Here, we report results on a subgroup studied so far. 10 patients with ET (mean age 67.7 +- 4.…