Good outcome in a patient with prolonged comatose state, critically elevated serum neuron-specific enolase and electroencephalic burst-suppression pattern

Introduction: The neurological outcome after cardiopulmonary resuscitation (CPR) is limited by the susceptibility of neurons to the lack of oxygen. Up to 70% of patients with successful restoration of spontaneous circulation (ROSC) later reach a state with severe neurological impairment. Several parameters have been identified in order to predict the neurological outcome after CPR. Prolonged or late-onset CPR, serum neuron-specific enolase (sNSE) values beyond time-related thresholds (33µg/l within 24 hours, 24–33µg/l within 48 hours, 35–40µg/l within 72 hours after ROSC), neurophysiological investigation reveal…