CareLit Fachartikel
Lactacidosis modulates glutathione metabolism and oxidative glutamate toxicity
J Lewerenz, R Dargusch, P Maher · Aktuelle Neurologie · 2009 · Heft 10
Dokument
1105212
CareLit-ID
Jahr
2009
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
In cerebral ischemia, reduced blood flow results in lactate accumulation and subsequent tissue acidosis. Lactate and acidosis have been demonstrated to increase infarct size in humans and in animal models of cerebral ischemia. Oxidative glutamate toxicity is a form of glutamate-induced nerve cell death, where glutamate inhibits cystine uptake via the cystine/glutamate antiporter system xc-. Cystine is an essential building block of glutathione, the major small molecule antioxidant in the brain. Consequently, glutathione depletion leads to accumulation of reactive oxygen species and, ultimately, programmed cell d…
Schlagworte
Acidosis
Cystine
Reactive Oxygen Species
Antiporter
Blood
Aktuelle Neurologie
