High dose mistletoe treatment inhibits tumor growth and improves survival of B16.F10 melanoma bearing mice

Melanoma is the most aggressive skin cancer with increasing incidence and still poor prognosis. Because of the low response rates (˜20%) towards the standard chemotherapeutic agent dacarbazine (DTIC), new approaches for melanoma therapy are required. Our therapeutical approach is the use of mistletoe extractions for cancer and especially melanoma treatment in animal models. We show here antitumoral effects of aqueous mistletoe extracts in a mouse melanoma model with immunocompetent C57BL/6 mice and syngeneic B16.F10 melanoma cells. B16.F10 mouse melanoma cells were inoculated subcutaneously into the flanks of C5…