In vivo tracking of 111In-Oxine labeled mesenchymal stem cells following infusion in patients with advanced cirrhosis

Aims: Several animal studies and a few human studies suggest the beneficial role of bone marrow mesenchymal stem cells (MSCs) in liver cirrhosis. However, little is known about the fate of MSCs after infusion in cirrhotic patients. We evaluated stem cell bio-distribution after peripheral infusion of MSCs in cirrhotic patients. Methods: After three passages of MSCs, the first patient (F, 62y/o) received a total of 270×106 cells and the second (M, 17y/o) received 290×106 cells. A specific activity of 0.67MBq/106cells and 0.71MBq/106cells were maintained for the injected labeled cells of the first and second patien…