CareLit Fachartikel
The common bile salt export pump (ABCB11) p.A444V variant is associated with BMI levels in the general population
M Krawczyk, M Rusticeanu, F Grünhage, F Lammert · Zeitschrift für Gastroenterologie · 2009 · Heft 09
Dokument
1105368
CareLit-ID
Jahr
2009
Publikation
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Zusammenfassung
Introduction: ABCB11 is a member of the ATP-binding cassette (ABC) transporters functioning as canalicular bile salt export pump. Mutations in the ABCB11 gene cause progressive familial intrahepatic cholestasis and polymorphisms in the G6PC2/ABCB11 region have been associated with fasting glucose levels in humans [1, 2]. The aim of the current study was to investigate if the common ABCB11 variant p.A444V known to affect the expression level of this hepatobiliary transporter is associated with higher BMI levels in the general population. Materials and methods: We collected data including BMI from 277 German indiv…
Schlagworte
Population
Cholestasis
Absorption
Obesity
Affect
ANOVA
Zeitschrift für Gastroenterologie
