The functional CCL2 promotor polymorphism -2518A>G is no risk factor for the development of spontaneous bacterial peritonitis and survival in decompensated liver cirrhosis
F Grünhage, B Appenrodt, M Gentenmann, L Thyssen, S Schwartz, T Sauerbruch, F Lammert · Zeitschrift für Gastroenterologie · 2009 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aims: Factors influencing the development of spontaneous bacterial peritonitis (SBP) are poorly understood. We have recently shown that mutations in the nucleotide-binding oligomerization domain containing-2 (NOD2) gene are associated with the development of SBP and survival in patients with liver cirrhosis (Appenrodt B. et al. submitted). Clinical and experimental data also suggest that peritoneal macrophages contribute to the control of SBP via the chemokine CCL2 (MCP-1). Recently it was shown that a functional promoter variant in the CCL2 gene is associated with SBP in patients with alcoholic cirrhosis (Gäble…
