CareLit Fachartikel
Wnt-signaling and glutamine synthetase expression in human hepatocellular carcinomas
FH Gaunitz, M Austinat, M Werth, R Gebhardt · Zeitschrift für Gastroenterologie · 2007 · Heft 01
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1105873
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Jahr
2007
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Zusammenfassung
The liver specific expression of enzymes under normal conditions and in pathological situations is still enigmatic. Recently, the phenomenon of differential expression of enzymes along the porto-central axis of the liver acinus was demonstrated to be dependent on signal transduction pathways that are also important for the development of hepatocellular carcinoma (HCC). Most attention was drawn on the wnt-signaling pathway and its components beta-catenin and APC. Interestingly, the most prominent example of zonated expression in the normal liver –that of glutamine synthetase (GS) around the central veins- was sho…
Schlagworte
STAT5
Wnt
beta-catenin
glutamine synthetase
beta Catenin
Attention
Axis
Zeitschrift für Gastroenterologie
