Identification of microRNA differentially expressed in hepatocellular carcinoma versus non-tumoral liver tissue
M Scheffler, H Varnholt, E Konze, V Dries, U Drebber, P Schirmacher, F Schulze, HP Dienes, M Odenthal · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Bibliografische Angaben
Zusammenfassung
MicroRNAs (miRNAs) are small, endogenously expressed, noncoding RNAs, which regulate gene expression through RNA interference by binding to a defined set of target transcripts. Recent data have shown that miRNAs are involved in cancer initiation and progression by affecting tumorigenic pathways with impact on cell proliferation and apoptosis. Since miRNA expression pattern can be used for the classification, prognosis and therapeutic approaches of human malignancies, we studied the miRNA expression profiles by quantitative PCR in hepatocelluar carcinoma (HCC). Methods: From a total of 74 HCCs, tissues from HCV p…
