CareLit Fachartikel

Adenoviral gene delivery of interleukin-10 reduces hepatic ischemia-reperfusion injury in rats

M Froh, P Walbrun, S Netter, R Wiest, E Gäbele, J Schölmerich, C Hellerbrand · Zeitschrift für Gastroenterologie · 2007 · Heft 01

Dokument
1105876
CareLit-ID
Jahr
2007
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
M Froh, P Walbrun, S Netter, R Wiest, E Gäbele, J Schölmerich, C Hellerbrand
Ausgabe
Heft 01 / 2007
Seiten
–
Erschienen: 2007-01-23 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2007-967837

Zusammenfassung

Aims: Ischemia-reperfusion injury to the liver occurs in trauma, hemorrhagic shock, and after hepatic surgery, including tumor resection and transplantation. Reactive oxygen species, produced by activated macrophages (in particular Kupffer cells) and neutrophils, play a critical role in the injury caused by ischemia-reperfusion. The multifunctional cytokine Interleukin–10 (IL–10) is known for its ability to inhibit activation and effector function of T cells, monocytes, and macrophages. AIM: Here, we investigated the effect of adenoviral gene delivery of IL–10 in an acute model of hepatic oxidative stress. Metho…

Schlagworte

After Reactive Oxygen Species Cytokine Blood Transplantation Tumor Zeitschrift für Gastroenterologie