CareLit Fachartikel
Sensitization of hepatocytes by methyltransferase-inhibitor 5-azacytidine against cytokine-mediated cell death
T Weiland, A Wendel, G Künstle · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Dokument
1105881
CareLit-ID
Jahr
2007
Publikation
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Metadaten
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Zusammenfassung
Background 5-Azacytidine (5-aza-CR) was developed as an antineoplastic agent long before its inhibitory activity on DNA methyltransferases and thus its ability to reverse aberrant gene silencing became evident. Today, 5-aza-CR is the first DNA hypomethylating agent approved for treatment of myelodysplastic syndromes and represents a promising drug for epigenetic cancer therapy. However, 5-aza-CR is contraindicated for patients with pre-existing liver diseases due to adverse liver effects for yet unknown reasons. Aims: For a comprehensive understanding of the pharmacodynamic properties of 5-aza-CR it is mandatory…
Schlagworte
HepG2
TNF
apoptosis
death receptors
Caspase 8
Chromatin
Caspases
After
Cytokine
Zeitschrift für Gastroenterologie
