The Lipolysis Stimulated Receptor – A Novel Contender on the Diabetes Arena?

Type 2 Diabetes is among the fastest spreading diseases worldwide. It is characterized by the insensitivity of peripheral organs to insulin. Although several factors such as genetic predisposition, obesity, aging, environmental conditions and life style trigger its development, the intricate mechanisms of insulin resistance remain largely unclear. Therefore, we aimed to identify hormone – dependent regulation of genes involved in the development of hepatic insulin resistance using cDNA microarray technology. We performed transcriptional profiling of insulin – dependent and counter – regulatory signaling pathways…