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The expression of microRNAs on rat chromosome 6q32 may be involved in type 1 diabetes development of BB rats

P Lutze, R Baguhl, I Klöting · Diabetologie und Stoffwechsel · 2007 · Heft 08

Dokument
1106214
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Jahr
2007
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
P Lutze, R Baguhl, I Klöting
Ausgabe
Heft 08 / 2007
Seiten
–
Erschienen: 2007-08-16 00:00:00
ISSN
1861-9002
DOI
10.1055/s-2007-982157

Zusammenfassung

Aim: Eighty nine per cent of BB/OK rats develop type 1 diabetes up to an age of 30 weeks whereas S(pontaneous) H(ypertensive) R(ats) are disease resistant. Crossing studies of these strains revealed a diabetogenic region on chromosome 6 (D6Rat66-D6Rat3). This segment was introgressed onto BB/OK genetic background using male or female SHR as segment donor generating congenic BB.SHR briefly termed BB.6Sm(ale donor) or BB.6Sf(emale donor). Congenic BB.6Sm developed diabetes with a frequency of 14% whereas BB.6Sf developed diabetes with a frequency which was comparable with those of BB/OK rats. That prompted us to a…

Schlagworte

Expression Diabetes Mirnas Donor Adipose Tissue Subcutaneous Segment Congenic Frequency Visceral Chromosome Diabetologie und Stoffwechsel