CareLit Fachartikel

TCF7L2-gene polymorphisms confer an increased risk for early impairment of glucose metabolism and increased height in obese children

A Körner, P Kovacs, J Berndt, M Stumvoll, W Kiess · Diabetologie und Stoffwechsel · 2007 · Heft 08

Dokument
1106224
CareLit-ID
Jahr
2007
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
A Körner, P Kovacs, J Berndt, M Stumvoll, W Kiess
Ausgabe
Heft 08 / 2007
Seiten
–
Erschienen: 2007-08-16 00:00:00
ISSN
1861-9002
DOI
10.1055/s-2007-982257

Zusammenfassung

Variants in the TCF7L2-gene have been associated with increased risk for type 2 diabetes in adults. To evaluate whether these risk variants confer a higher risk for obesity and early impairment of glucose metabolism in children, we genotyped five risk variants of the TCF7L2-gene in a representative cohort of 1029 Caucasian children and in an independent cohort of 283 obese children. Applying a case control design, we observed a significantly lower prevalence of the rs11196205 and rs7895340 risk alleles in the obese compared to lean children (0.40 vs. 0.45, P=0.02). There was, however, no statistical significant…

Schlagworte

Alleles Obesity Blood Glucose Acceleration Autoimmunity Blood Diabetologie und Stoffwechsel