Decreased HCHO pool measured in erythrocytes in colorectal cancer patients after colectomy

Introduction: In neoplasia „methylation imbalance“ can be observed. Hypomethylation is accompanied by localized hypermetylation. HCHO can be formed through methylating, demethylating and transmethylating reactions. Data show the importance of HCHO in proliferative as well as apoptotic processes and in the methylation of heme. Free protoporphyrin (FPP) can be observed in cancer and it has pro- and antioxidant properties with concentration dependence. The aims: to determine the HCHO and FPP concentrations of erythrocytes in colorectal cancer after colectomy and to establish the therapeutic effectiveness in the tum…