Dual effects of bile acids on guinea pig pancreatic ductal bicarbonate secretion
J Maléth, V Venglovecz, Z Rakonczay, L Nagy, B Ózsvári, T Takács, J Lonovics, A Tóth, A Varró, MA Gray, BE Argent, P Hegyi · Zeitschrift für Gastroenterologie · 2007 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aims: Exposure of the pancreas to bile acids is considered to be one of the possible causes of acute pancreatitis. However, no information is available on the effects of bile acids on intact pancreatic epithelia. Methods: Isolated guinea pig intra/interlobular pancreatic ducts were perfused from the luminal and basolateral membranes with standard Hepes or HCO3-/CO2 solutions. The effects of chenodeoxycholate (non-conjugated bile acid, CDC) and glycochenodeoxycholate (conjugated bile acid, GCDC) on intracellular pH (pHi) of pancreatic ductal epithelial cells (PDEC) were measured using the fluorescent dye BCECF an…
