CareLit Fachartikel
Cytokine secretion by hUCB-derived mononuclear cells – a putative mediator of functional improvement after hypoxic-ischemic brain lesion?
S Neuhoff, K Rosenkranz, A Jensen, R Dermietzel, C Meier · Geburtshilfe und Frauenheilkunde · 2007 · Heft 06
Dokument
1106341
CareLit-ID
Jahr
2007
Publikation
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Metadaten
DOI
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Zusammenfassung
Intraperitoneal transplantation of human umbilical cord blood-derived mononuclear cells led to the “homing“ of these cells specifically to a hypoxic-ischemic lesion in perinatal rats. Motor deficits resulting from the lesion were alleviated upon transplantation (1). However, the molecular and cellular mechanisms underlying the functional improvement are still unclear. As neuronal differentiation of transplanted cells seems to be a rare or absent event in vivo, we propose secondary mechanisms, which might be responsible for the therapeutic effects. One possibility is that transplanted cells might contribute to a…
Schlagworte
Cytokines
Transplantation
After
Chemokines
Blood
Cytokine
Geburtshilfe und Frauenheilkunde
