Reducing the incidence of complications over patient lifetimes: A modeling analysis of insulin detemir versus NPH in German type 2 diabetes patients

Aims: To evaluate the time to onset and long-term cumulative incidence of diabetes-related complications in type 2 diabetes patients receiving either insulin detemir (Levemir, Novo Nordisk) or NPH in the German setting based on the findings of a recent observational study. Material and Methods: A validated computer simulation model of type 2 diabetes was used to make long-term projections of clinical outcomes based on patient characteristics and treatment effects from the German cohort of the PREDICTIVE observational study. The trial demonstrated that therapy conversion from NPH to insulin detemir was associated…