Initial radiographic response predicts favorable outcome to chemotherapy in primary CNS lymphoma
HJ Pels, A Jürgens, I Schirgens, A Glasmacher, H Schulz, A Engert, V Diehl, M Linnebank, G Schackert, H Reichmann, F Kroschinsky, M Vogt-Schaden, G Egerer, U Bode, M Deckert, R Fimmers, K Fliessbach, P Calabrese, T Klockgether, IGH Schmidt-Wolf, U Schlegel · Aktuelle Neurologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Objective: The identification of prognostic factors in primary CNS lymphoma (PCNSL) is useful for treatment stratification in randomized trials and for decision making in the individual patient. Prognostic factors in PCNSL are age and performance status and possibly others. To evaluate the prognostic impact of tumor response to initial systemic and intraventricular chemotherapy cycles during ongoing treatment as assessed by magnetic resonance imaging (MRI). Patients and methods: From 09/1995 to 12/2002, 88 patients with PCNSL were enrolled in a pilot/phase II study evaluating MTX-based high-dose chemotherapy wit…
