Autosomal dominant spastic paraplegia with sensory deficits and muscle wasting (SPG36) maps to chromosome 12q23–24

Background: Spastic paraplegias are a genetically heterogenous group of disorders. So far, over 30 genes or loci for SP have been described, among them 13 loci for autosomal dominant disease. Objective: Mapping of a novel autosomal dominant SP locus, sequencing of candidate genes and phenotypic description. Design/methods: A genome wide linkage analysis using Human Mapping 10K SNP Microarrays was performed in a large three generation family with pure autosomal dominant SP. Linkage to known loci of autosomal dominant SP loci was excluded previously. DNA of 14 family members (7 affected, 7 healthy) was available.…