Effectiveness of topiramate in patients with epilepsy transitioning from valproic acid – results of an open-label, non-interventional trial

Objective: To evaluate seizure frequency and tolerability in patients with epilepsy treated with topiramate (TPM, Topamax®) transitioning from valproic acid (VPA). Methods: Multicenter open-label non-interventional trial (TOPMAT-EPY-403) following patients ≥12 years of age with epilepsy previously unsuccessfully treated with VPA. Patients were prospectively followed for 20 weeks after transitioning to TPM. A 12-week retrospective seizure frequency was used as baseline. Results: 147 patients (59% female; mean age 42yrs (±SD 19)) were followed. Median duration of epilepsy was 9yrs (range, 0–60yrs). 77% had seizure…