Sequence variation in the gene encoding soluble epoxide hydrolase (EPHX2) is associated with increased susceptibility to ischemic stroke in a central european population

Background and purpose: Recent evidence suggests that genetic variation in the EPHX2 gene region modifies individual risk of ischemic stroke. The role of EPHX2 has not yet been explored with regard to stroke subtypes, however. Our goal was to replicate the original findings in a large and well-characterized sample of central European patients; additionally, we set out to examine the role of EPHX2 with regard to specific stroke subtypes. Methods: We genotyped 26 single nucleotide polymorphisms (SNPs) in the EPHX2 gene region in a population of 601 stroke patients and 736 unrelated matched controls using a case-co…