Adenoviral B7-H3 therapy induces tumor specific immune responses and reduces secondary metastasis in a murine model of colon cancer

Introduction: Current cancer gene therapies aim for the induction of systemic antitumor immune responses. Tumors may deliver antigens to T cells, but may lack the costimulatory signals necessary for mounting an effective response. Aims: The purpose of this study was to evaluate the efficacy of an adenoviral delivery of the B7-H3 costimulatory molecule in mice to induce antitumor immune responses. Methods: Colon cancers were established by orthotopic injection of syngeneic colon cancer cells into the cecum on Balb/c mice. After two weeks theses mice were treated by intratumoral injection of an adenovirus expressi…