Effect of gastric secretion on gastric volume responses, emptying and intragastric dilution in humans – a magnetic resonance imaging (MRI) study

Aims: The formation of unbuffered gastric acid layers by gastric secretions after ingestion of a meal is important for understanding gastroesophageal reflux. Hitherto, a visualization of these phenomena and their relationship to meal and stomach volume was not possible. We have developed a novel T1 mapping technique allowing the quantitative assessment of dilution processes of meals. Aims: To evaluate the effect of pentagastrin induced gastric secretion on gastric volume responses and intragastric spatial and temporal dilution of a liquid meal by MRI. Methods: Using a 1.5T MRI System, 12 volunteers were examined…