The transcription factor interferon regulatory factor-4 controls experimental colitis via IL-6/sIL-6R
J Mudter, L Amoussina, M Schenk, A Bruestle, B Weigmann, J Yu, S Wirtz, PR Galle, HA Lehr, S Rose-John, C Müller, M Lohoff, MF Neurath · Zeitschrift für Gastroenterologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
The interferon regulatory factor-4 (IRF4) is a central player in T cell regulation and differentiation. In the present study, we assessed the functional role of IRF4 in the immunopathogenesis of experimental colitis. As our previous data have shown, the number of IRF4 expressing mucosal T cells from IBD patients is increased compared with control patients. Consistently, adoptive transfer of wild-type but not IRF-4 deficient T cells resulted in severe colitis in reconstituted RAG deficient mice. Furthermore, IRF-4 knockout mice were protected from T cell dependent chronic intestinal inflammation in TNBS- and oxaz…
