CareLit Fachartikel

SP and CGRP differentially modulate epithelial cell restitution via expression of TGF-beta, TGF-alpha and EGF-Receptor RNA in fibroblasts and mast-cells in an in vitro wound assay

K Bulut, P Felderbauer, K Hoeck, S Deters, WE Schmidt, P Hoffmann · Zeitschrift für Gastroenterologie · 2007 · Heft 09

Dokument
1106575
CareLit-ID
Jahr
2007
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
K Bulut, P Felderbauer, K Hoeck, S Deters, WE Schmidt, P Hoffmann
Ausgabe
Heft 09 / 2007
Seiten
–
Erschienen: 2007-09-05 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2007-988417

Zusammenfassung

Aims: Substance P (SP) and calcitonin gene related peptide (CGRP) are neurotransmitters of the extrinsic afferent sensory nervous system. In experimental animal models of colitis, a protective role of SP and CGRP on intestinal mucosa was presumed. The mucosal protection in part depends on a SP and CGRP mediated modulation of mucosal blood flow after injury, but other mechanism seem to add to that protective effect. We demonstrate a mast cell and fibroblast mediated effect of SP and CGRP on epithelial cell restitution in vitro and identified potential contributing cytokines. Methods: Mast cell and rat kidney fibr…

Schlagworte

After Calcitonin Gene-Related Peptide Intestinal Mucosa Observation Calcitonin Cytokines Blood Zeitschrift für Gastroenterologie