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Obstructive cholestasis down-regulates Oatp1 by TNFα signalling without affecting Oatp2 and Oatp4 expression and Sodium-independent bile salt uptake in rat liver

A Geier, CG Dietrich, M Trauner, C Gartung · Zeitschrift für Gastroenterologie · 2007 · Heft 09

Dokument
1106587
CareLit-ID
Jahr
2007
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
A Geier, CG Dietrich, M Trauner, C Gartung
Ausgabe
Heft 09 / 2007
Seiten
–
Erschienen: 2007-09-05 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2007-988537

Zusammenfassung

Background & Aims: Hepatic uptake of bile salts is mediated by sodium-dependent and sodium-independent transport systems. During extrahepatic cholestasis both function and expression of the Na+/taurocholate cotransporting polypeptide (Ntcp) are down-regulated. To test whether hepatic sodium-independent organic anion transporting polypeptides (Oatp1/Oatp1a1, Oatp2/Oatp1a4, Oatp4/Oatp1b2) are also affected by extrahepatic cholestasis, function and expression of all three Oatps have been determined in rats subjected to common bile duct ligation (CBDL; n=4) for up to 7 days with and without anti-cytokine pretreatmen…

Schlagworte

Cholestasis After Cytokine Cholate Anakinra Zeitschrift für Gastroenterologie